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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6(SJL)-Slc6a8tm1.1Clar/J (Cat. No.: CEMM-07250428) | Inquiry | |
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The CrTflox (Slc6a8fl) conditional allele has loxP sites flanking the regions encoding the 2nd-4th transmembrane domain of the creatine transporter gene on the X chromosome. These CrTflox mice are a Cre-lox tool for generating tissue-specific CrT deletions, and may be useful for studying creatine transport and human X-linked creatine deficiency syndrome, mental retardation, autism, and speech, language, cognitive, and memory disorders.
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| STOCK Grm7Tg(SMN2)89Ahmb Smn1tm1Jme/J (Cat. No.: CEMM-07250964) | Inquiry | |
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SMN2;SMNF7 double mutant mice (also called Tg(SMN2)89;SMNF7) harbor a human SMN2 transgene and the SMNF7 floxed allele. Exposure to Cre recombinase removes the floxed sequence (Smn1 exon 7) - creating a null allele. These SMN2;SMNF7 mice may be useful for Cre-inducible studies related to human spinal muscular atrophy (SMA) or other neuromuscular degenerative diseases.
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| STOCK Et(cre)TFC.09Lois/J (Cat. No.: CEMM-07250550) | Inquiry | |
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The Thy1.2-Cre enhancer trap transgenic mouse line 09 (TFC.09) expresses Cre recombinase sparsely in a small number of cortical progenitor cells during early forebrain development. GFP expression is almost undetectable by fluorescence and it is only transiently expressed in a few stem cells in the embryo. TFC.09 mice allow examination of individual columns and cells, and may be useful for investigating patterns of neural development in the neocortex, as well as for studying cell lineage in mouse brain.
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| B6(Cg)-Tg(Snap25-FLPe)47DSJDJdd Tg(Egr1-cre/ERT2)47DSJDJdd/J (Cat. No.: CEMM-07250965) | Inquiry | |
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Egr1-Cre-ERT2; Snap25-Flpe (ECSF) bi-transgenic BAC mice were originally designed to enable selective genetic targeting of non-myelinated Remak Schwann cells. Mice carry both a tamoxifen-inducible/FRT-flanked Cre recombinase driven by the mouse Egr1 promoter (expressed in Remak Schwann cells and some neurons), and Flpe recombinase driven by the Snap25 promoter (associated with pan-neuronal expression). Though anticipated to be complete, depletion of neuronal Cre activity by Flpe is partial, with some neurons and astrocytes also showing evidence of Cre reporter activity in the central and peripheral nervous systems. As such, this mouse line will be useful in mosaic loss-of-function studies, lineage tracing studies following injury, and live cell imaging studies or other experiment benefiting from sparse labeling.
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| STOCK Tcf12tm3Zhu Tcf3tm4Zhu/J (Cat. No.: CEMM-07250542) | Inquiry | |
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HEBf E2Af mice allow Cre-recombinase inducible deletion of the two basic helix-loop-helix (bHLH) E-protein family genes HEB and E2A. These mice may be useful for studying B and T lymphocyte development and lymphoid malignancies.
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| FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J (Cat. No.: CEMM-07250355) | Inquiry | |
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These CAGGCre-ERTM transgenic mice have widespread expression of a tamoxifen-inducible Cre recombinase.
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| C57BL/6J-Il2rgem1Lutzy/J (Cat. No.: CEMM-07250943) | Inquiry | |
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B6J.Il2rg cKO (Il2rg flox exon 3) is a CRISPR/Cas9 generated mutant of the interleukin 2 receptor, gamma chain locus having loxP sites flanking exon 3. While this Il2rg cKO allele is expected to result in a knock-out after exposure to Cre recombinase, that has not yet been specifically characterized to date [September 2021].These B6J.Il2rg cKO mice may be useful for Cre-lox studies of NK cell development, innate immunity, T and B cell deficiency and xenograft/transplant research.
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| B6.Cg-Brs3tm1.1(cre/GFP)Rpa/J (Cat. No.: CEMM-07250808) | Inquiry | |
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IRES-cre is expressed from the mouse Brs3 promoter in Brs3-expressing cells of the parabrachial nucleus (PBN).
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| STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J (Cat. No.: CEMM-07250009) | Inquiry | |
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These Z/AP reporter mice express a transgene containing a floxed Beta-geo and the human placental alkaline phosphatase gene with widespread expression of lacZ except in erythrocytes, chondrocytes and adipocytes.
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| B6.Cg-H2az2Tg(Wnt1-cre)11Rth Tg(Wnt1-GAL4)11Rth/J (Cat. No.: CEMM-07250152) | Inquiry | |
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Wnt-1/GAL4/cre-11 transgenic mice were created by co-injection of both the pWEXP2-GAL4 transgene (Wnt1-GAL4) and the pWEXP3C-cre transgene (Wnt1-Cre). Transgenic mice have the wingless-related MMTV integration site 1 (Wnt1) promoter/regulatory sequences directing expression of both Cre recombinase and the GAL4 transcriptional activator to midbrain and developing neural tube. Wnt-1/GAL4/cre-11 mice exhibit transgenic overexpression of Wnt1, both within and outside of the expected pattern of expression, which results in increased activation of WNT signaling, along with midbrain enlargement and accompanying loss of midbrain dopaminergic neurons. Further, it was reported that the Wnt1-cre transgene integrated into chromosome 11 causing a 31,283 bp deletion in the H2afv locus. In, founder line 1 had a copy number of greater than 5.
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For Research Use Only.