FVB.Cg-Tg(CAG-cre/Esr1*)5Amc/J

Tg(CAG-cre/Esr1*)5Amc

transgene insertion 5

Recombinase-expressing; Inducible

Tg(CAG-cre/Esr1*)5Amc

transgene insertion 5

UN

cre/Esr1, Cre recombinase and estrogen receptor 1 fusion gene

2182767

Tamoxifen-inducible cre; widespread pattern of expression; Tamoxifen administration will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice

(C57BL/6 x CBA)F1

This transgene expresses a fusion protein consisting of Cre recombinase joined to the ligand-binding domain of a mouse estrogen receptor modified to bind to 4-hydroxytamoxifen, but not to endogenous estrogen. The CAG promoter, containing a chicken beta actin promoter/enhancer coupled with the cytomegalovirus immediate-early (CMV-IE) enhancer, drives high levels of expression in most tissues. In the presence of tamoxifen, the fusion protein is transported into the nucleus, where Cre can excise loxP-flanked segments from conditionally modified genes.

FVB/NJ Noncarrier

These mice were bred to FVB/NJ inbred mice for many generations using a marker-assisted, speed congenic approach to generate this FVB/NJ-congenic strain. When maintaining the live congenic colony, carrier mice may be bred with wildtype (non-carrier) mice from the colony or with FVB/NJ inbred mice.