B6(Cg)-Tg(Snap25-FLPe)47DSJDJdd Tg(Egr1-cre/ERT2)47DSJDJdd/J

Common Name: Egr1-Cre-ERT2; Snap25-Flpe (ECSF)

Egr1-Cre-ERT2; Snap25-Flpe (ECSF) bi-transgenic BAC mice were originally designed to enable selective genetic targeting of non-myelinated Remak Schwann cells. Mice carry both a tamoxifen-inducible/FRT-flanked Cre recombinase driven by the mouse Egr1 promoter (expressed in Remak Schwann cells and some neurons), and Flpe recombinase driven by the Snap25 promoter (associated with pan-neuronal expression). Though anticipated to be complete, depletion of neuronal Cre activity by Flpe is partial, with some neurons and astrocytes also showing evidence of Cre reporter activity in the central and peripheral nervous systems. As such, this mouse line will be useful in mosaic loss-of-function studies, lineage tracing studies following injury, and live cell imaging studies or other experiment benefiting from sparse labeling.