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Customized Rat Models
Rats are a commonly used animal model organism in scientific research, particularly in the fields of biology, pharmacology, and toxicology. Creative Biogene offers customized rat modeling service with site-specific recombinase technologies for research use.
Introduction into Mouse Models Generated by T-SSR System
Site-specific recombinase system is widely used in generating rat models, which have been widely used in biomedical research to study gene function and disease mechanisms. These models are created by introducing DNA constructs containing recombinase recognition sites, called loxP sites, into the genome of rats. By crossing these rats with other rats expressing recombinase enzymes, such as Cre or Flp, specific genes or regions of DNA can be selectively deleted, modified, or activated in a tissue-specific manner.
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The limitation of the application of rat models are the inability to genetically modification in rat genome. Therefore, many optimized T-SSR systems have been developed for generating genetically engineered rat models, such as split-Cre, combination of CRISPR and Cre system, and many other technologies.
Advantages of Rat as Model
As a mammalian model, rat offers several advantages over other traditional models, such as mice and fruit flies.
- Large size: Rats are larger than mice and many other model organisms, which makes them easier to work with and allows for easier manipulation and surgical procedures.
- Similarity to humans: Rats are more similar to humans in terms of anatomy, physiology, and behavior, making them a better model for human diseases and drug development.
- Longer lifespan: Rats have a longer lifespan than mice, which allows for the study of long-term effects of drugs and diseases.
- Genetic diversity: Rats have a higher genetic diversity than mice, which makes them more suitable for studying complex genetic diseases and traits.
- Behavioral complexity: Rats have a complex social and behavioral repertoire, making them useful for studying various aspects of behavior and cognition.
- Disease models: Rats are useful for creating disease models, including models for cardiovascular disease, diabetes, and cancer.
Our Service
Creative Biogene offers rat model generation service based on site-specific recombinase. With our advanced technologies and years of experience, we provide customized rat model service as follows:
Why Choose Us
One-stop Service
High-efficiency
Professional Team
High-quality
Creative Biogene has years of experience in site-specific recombinase-based applications. We have established the advanced CreEditTM platform, which aims to support our global customers with high-quality, cost-effective and high-precision one-stop services. Our services are not limited in what we mentioned above, please feel free to contact us and get started with our first-class services.