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Customized Mouse Models
Mouse models generated using the site-specific recombination system are a powerful tool in genetic research, as they allow researchers to manipulate specific genes within the mouse genome. Creative Biogene offer customized mouse model generation service based on site-specific recombinase system, with guaranteed quality and precision.
Mouse Models Generated by T-SSR System
Site-specific recombinase (SSR) technology is a genetic engineering technique that allows for the precise manipulation of DNA sequences in living cells. This technology has been widely used to generate genetically engineered mouse models that are useful for studying gene function and disease mechanisms.
In these mouse models, SSR enzymes, such as Cre or Flp, are used to catalyze recombination between two specific DNA sequences, known as loxP or FRT sites, respectively. By strategically placing these sites within the mouse genome, researchers can create a wide variety of genetic modifications, including gene deletion, gene inversion, gene insertion, and conditional gene activation or inactivation.
Cre/loxP tissue-specific KO mouse
One of the major advantages of SSR technology is its precision, allowing for highly specific targeting of genes and cell types. For example, conditional gene knockout models can be created by introducing loxP sites flanking a specific gene of interest, which allows for gene deletion in a tissue-specific or inducible manner. This technique has been especially useful for studying gene function in complex systems, such as the brain, where traditional knockout models may be lethal or result in widespread effects.
Our Service
Creative Biogene offers mouse models generation service based on site-specific recombinase systems. With the advanced technology and years of experience, we generate mouse models that are powerful tools for various areas, including neurology, oncology, cardiovascular disease, and more. Our services are included but not limited as follows.
Applications of Our Service
- Targeted gene modification: SSR technology allows for precise modification of specific genes, allowing for the study of gene function in vivo.
- Tissue-specific gene modification: SSR technology can be used to modify genes in specific tissues, which enables the study of gene function in particular organs or cell types.
- Inducible gene modification: Some SSR systems can be induced to modify genes at specific times or under certain conditions, which allows for the study of gene function under specific circumstances.
- Neurological disease modeling: Site-specific recombinase technology has been used to create mouse models of neurological diseases such as Alzheimer's and Parkinson's disease. These models are used to study the underlying mechanisms of these diseases and develop new treatments.
- Developmental biology research: By deleting or modifying genes in specific tissues or at specific developmental stages, researchers can investigate the function of these genes and their role in development.
Why Choose Us
One-stop Service
High-efficiency
Professional Team
High-quality
Creative Biogene has years of experience in site-specific recombinase-based applications. We have established the advanced CreEditTM platform, which aims to support our global customers with high-quality, cost-effective and high-precision one-stop services. Our services are not limited in what we mentioned above, please feel free to contact us and get started with our first-class services.