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STOCK Grm7Tg(SMN2)89Ahmb Smn1tm1Jme/J

Cat. No.: CEMM-07250964

Common Name: SMN2; SMNF7 [or Tg(SMN2)89; SMNF7]
SMN2;SMNF7 double mutant mice (also called Tg(SMN2)89;SMNF7) harbor a human SMN2 transgene and the SMNF7 floxed allele. Exposure to Cre recombinase removes the floxed sequence (Smn1 exon 7) - creating a null allele. These SMN2;SMNF7 mice may be useful for Cre-inducible studies related to human spinal muscular atrophy (SMA) or other neuromuscular degenerative diseases.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Smn1tm1Jme
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Allele Name
targeted mutation 1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Smn1
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Gene Name
survival motor neuron 1
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Chromosome
13
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MGI Accession ID
2384151
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Site of Expression
Human SMN2 protein is expressed in the tissues examined (brain, liver, spinal cord).
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Strain of Origin
129
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Molecular Note
A floxed exon 7 and neomycin resistance cassette were introduced to the gene via homologous recombination. The floxed exon 7 and neo cassette do not appear to interfere with transcript splicing in mutant animals as determined by RT-PCR analysis.
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HUSBANDRY
Breeding Considerations
The Tg(SMN2)89 transgene insertion into the glutamate receptor metabotropic 7 locus (Grm7Tg(SMN2)89Ahmb) on chromosome 6 and the SMNF7 floxed allele (Smn1tm1Jme) on chromosome 13 are not linked and will segregate independently. Prior to introduction of Cre recombinase, mice homozygous for both alleles (SMN2+/+;SMNF7/F7) are viable and fertile with no reported gross physical or behavioral abnormalities.
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Breeding Strategy
HOM X HOM
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For Research Use Only.
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