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STOCK Tcf12tm3Zhu Tcf3tm4Zhu/J
Cat. No.: CEMM-07250542
Common Name: HEBflox E2Aflox
HEBf E2Af mice allow Cre-recombinase inducible deletion of the two basic helix-loop-helix (bHLH) E-protein family genes HEB and E2A. These mice may be useful for studying B and T lymphocyte development and lymphoid malignancies.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tcf3tm4Zhu
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| Allele Name |
targeted mutation 4
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Tcf3
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| Gene Name |
transcription factor 3
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJaeSor
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| Molecular Note |
A targeting construct was engineered to contain a 5' loxP site in an intron upstream of the bHLH sequence, common to both E12 and E47 isoforms, and a 3' loxP site downstream of the endogenous locus. Also included in the construct were neo and lacZ genes, respectively positioned upstream and downstream of the 3' loxP site. The construct was designed such that the lacZ gene will be transcribed only upon recombination of the loxP sites.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
These HEBf E2Af mice harbor two mutations that segregate independently; the HEB floxed allele (Tcf12tm3Zhu) and E2A floxed allele (Tcf3tm4Zhu). When maintaining a live colony, mice homozygous for both floxed mutations may be bred together.
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For Research Use Only.
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