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STOCK Tg(CAG-Bgeo/ALPP)1Lbe/J
Cat. No.: CEMM-07250009
Common Name: Z/AP reporter
These Z/AP reporter mice express a transgene containing a floxed Beta-geo and the human placental alkaline phosphatase gene with widespread expression of lacZ except in erythrocytes, chondrocytes and adipocytes.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(CAG-Bgeo/ALPP)1Lbe
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| Allele Name |
transgene insertion 1
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| Allele Attributes |
Reporter
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| Gene Symbol |
Tg(CAG-Bgeo/ALPP)1Lbe
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| Gene Name |
transgene insertion 1
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| Chromosome |
UN
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| Expressed Genes |
Bgeo, fusion of beta-galactosidase and neomycin phosphotransferase genes, E. coli; ALPP, alkaline phosphatase, placental, human
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| MGI Accession ID | show more close |
| Site of Expression |
LacZ is widely expressed throughout embryonic and adult tissues with notable exceptions being erythrocytes, chondrocytes and adipocytes; When crossed with a Cre recombinase-expressing strain, LacZ expression is replaced with alkaline phosphatase expression
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
The transgene contains the CMV enhancer/chicken beta-actin promoter, a floxed Beta-geo reporter/SV40 polyadenylation signal segment, and the human placental alkaline phosphatase gene followed by a rabbit Hbb polyadenylation sequence. In transgenic mice expression of lacZ is widespread, with notable exceptions being erythrocytes, chondrocytes and adipocytes. This expression is observed throughout all embryonic and adult stages.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Noncarrier
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| Breeding Considerations |
This strain arose on the 129X1/SvJ x 129S1/Sv (R1 ES cell line) background and was maintained by the donating investigator as a hemizygote by crosses to wildtype outbred CD1 mice. It is unknown if homozygotes are viable. Coat color expected from breeding:Agouti
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For Research Use Only.
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