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C57BL/6J-Il2rgem1Lutzy/J
Cat. No.: CEMM-07250943
Common Name: B6J.Il2rg flox
B6J.Il2rg cKO (Il2rg flox exon 3) is a CRISPR/Cas9 generated mutant of the interleukin 2 receptor, gamma chain locus having loxP sites flanking exon 3. While this Il2rg cKO allele is expected to result in a knock-out after exposure to Cre recombinase, that has not yet been specifically characterized to date [September 2021].These B6J.Il2rg cKO mice may be useful for Cre-lox studies of NK cell development, innate immunity, T and B cell deficiency and xenograft/transplant research.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Il2rgem1Lutzy
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Il2rg
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| Gene Name |
interleukin 2 receptor
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
CRISPR/Cas9 genome editing is used to insert loxP sites flanking exon 3. Il2rg transcript Il2rg-201 was used as reference for the exon number and the guide sequences.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
This gene is X-linked. When maintaining a live colony, homozygous females may be bred to hemizygous males. Homozygous females and hemizygous males are viable and fertile with normal lymphocyte populations (i.e. not immunodeficient).
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| Breeding Strategy |
Homozygote x Hemizygote
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For Research Use Only.
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