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Customized Drosophila Models
Drosophila melanogaster, known as fruit fly, is a widely used model organism in biological research. Creative Biogene offers customized Drosophila model service for our global customers foe research use, based on out well-developed site-specific recombinase technologies.
Introduction into Drosophila Models Generated by T-SSR System
Drosophila melanogaster, or fruit flies, have been a popular model organism for genetic studies for over a century. Site-specific recombinase technology has further enhanced the utility of Drosophila as a model organism by enabling the precise manipulation of gene expression and function in a tissue-specific and temporally controlled manner.
One commonly used site-specific recombinase system in Drosophila is the Gal4-UAS system. In this system, a transgenic fly line carrying a gene encoding the Gal4 recombinase under the control of a specific promoter is crossed with another transgenic fly line carrying a gene of interest downstream of a UAS (upstream activating sequence) promoter. The Gal4 recombinase binds to the UAS promoter, resulting in the activation or repression of the gene of interest in specific tissues or developmental stages.
Two strategies of homologous recombination (Lin, Shih-Ching et al. 2014)
Drosophila models generated by site-specific recombinase technology have been used to study a variety of biological processes, including development, behavior, and disease. For example, researchers have used the Gal4-UAS system to study the role of specific genes in the development of the nervous system, the immune system, and the heart. They have also used this system to model human diseases such as Alzheimer's disease, Parkinson's disease, and cancer.
Advantages of Drosophila as Model Organism
Drosophila models generated by site-specific recombinase technology have become a powerful tool for studying gene function and disease. As a popular model organism, Drosophila has many advantages. Followings are some of them:
| Genetic tractability | Fruit flies have a relatively small genome, which makes them an ideal model organism for genetic studies. Researchers can easily manipulate the fly genome using a variety of genetic tools. |
| Short lifespan | Fruit flies have a short lifespan of about 60 days, which allows researchers to study multiple generations in a relatively short period. This is particularly useful for studying the genetic basis of aging and disease. |
| Easy to breed | Fruit flies are easy to breed and maintain in the laboratory. They have a high reproductive rate and can be reared on a simple, inexpensive diet. |
| Well-characterized biology | The biology of fruit flies is well-characterized, thanks in part to over a century of research. This makes it easy for researchers to design experiments and interpret results. |
| Homology with humans | Despite their evolutionary distance from humans, fruit flies share many genetic and molecular pathways with humans. This makes them a useful model organism for studying the genetic and molecular basis of human diseases. |
Our Service
Genetically engineered Drosophila is a powerful tool for studying a wide range of biological processes, from development and behavior to disease and drug discovery. Creative Biogene offers Drosophila models generation service based on our well-developed site-specific recombinase technologies. Our optimized T-SSR technologies allow for the study of gene function in specific cell types, which is essential for understanding the mechanisms of development and disease.
Why Choose Us
One-stop Service
High-efficiency
Professional Team
High-quality
Creative Biogene has years of experience in site-specific recombinase-based applications. We have established the advanced CreEditTM platform, which aims to support our global customers with high-quality, cost-effective and high-precision one-stop services. Our services are not limited in what we mentioned above, please feel free to contact us and get started with our first-class services.
Reference
- Lin, Shih-Ching et al. Strategies for gene disruption in Drosophila. Cell & bioscience vol. 4,1 63. 14 Oct. 2014.