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Customized C. elegans Models
Caenorhabditis elegans is a popular model due to its simplicity, small size, transparency, and ease of cultivation in the laboratory. And it is often used to study fundamental biological processes such as cell division, development, and apoptosis, as well as neurobiology, aging, and disease. Creative Biogene offer customized C. elegans modeling services to our global customers for assisting them making better breakthrough in their research area.
Introduction into C. elegans Generated by T-SSR System
Caenorhabditis elegans is an unsegmented pseudocoelomate and about 1 mm in length, which is often used as a model organism in biological research. Genetically engineered C. elegans strains generated with site-specific recombinase technology have been used in a variety of research applications, including development biology, neurobiology, aging and longevity, as well as disease mechanisms and gene functions.
Strategies of excision, inversion with Cre and FLP recombinase (Hubbard, 2014)
For example, the T-SSR system have been used to create conditional knockouts of specific genes in C. elegans, allowing for the study of gene function in specific tissues or developmental stages. T-SSR has also been used to create transgenic C. elegans strains that express fluorescent reporters or other genetic markers, which can be used to visualize and track specific cells or structures in the worm's body.
Advantages of C. elegans as Model Organism
As a widely used model organism, C. elegans has many advantages. Followings are some of them:
| Simple body plan | It has a simple and well-characterized body plan, with a total of 959 somatic cells in its adult hermaphrodite form. This simplicity makes it easier to study its development and gene function. |
| Short lifespan | It has a short lifespan of only two to three weeks, which allows for the study of aging and longevity in a relatively short amount of time. |
| Reproducible genetics | It reproduces via self-fertilization, which makes it possible to maintain and study large populations with nearly identical genetic backgrounds. |
| Transparent body | It is transparent, which allows for the observation of individual cells and subcellular structures in living animals using microscopy. |
| Large body of knowledge | It has been extensively studied for decades, resulting in a large body of knowledge about its biology, genetics, and development. This makes it an ideal organism for studying basic biological processes and for comparative studies with other organisms. |
| High conservation of gene function | Many genes and cellular processes in C. elegans are highly conserved across species, including humans. This makes it a valuable model organism for studying human diseases and for drug discovery. |
| Easy to maintain | It is easy to maintain in the laboratory, requiring minimal equipment and a simple nutrient agar medium as food. |
Our Service
The transparent body of C. elegans makes it easy to visualize cell division and differentiation, and its small size allows for high-throughput screening of genetic and chemical libraries. Additionally, C. elegans has a relatively short lifespan, allowing researchers to study the effects of genetic and environmental factors on aging and age-related diseases. Creative Biogene offers customized C. elegans modeling service based on site-specific recombinase technologies. Please view the following pages to check out the detailed information of our services.
Why Choose Us
One-stop Service
High-efficiency
Professional Team
High-quality
Creative Biogene has years of experience in site-specific recombinase-based applications. We have established the advanced CreEditTM platform, which aims to support our global customers with high-quality, cost-effective and high-precision one-stop services. Our services are not limited in what we mentioned above, please feel free to contact us and get started with our first-class services.
Reference
- Hubbard, E Jane Albert. FLP/FRT and Cre/lox recombination technology in C. elegans. Methods (San Diego, Calif.) vol. 68,3 (2014): 417-24.