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B6(SJL)-Slc6a8tm1.1Clar/J
Cat. No.: CEMM-07250428
Common Name: CrTflox; Slc6a8fl
The CrTflox (Slc6a8fl) conditional allele has loxP sites flanking the regions encoding the 2nd-4th transmembrane domain of the creatine transporter gene on the X chromosome. These CrTflox mice are a Cre-lox tool for generating tissue-specific CrT deletions, and may be useful for studying creatine transport and human X-linked creatine deficiency syndrome, mental retardation, autism, and speech, language, cognitive, and memory disorders.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Slc6a8tm1.1Clar
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Slc6a8
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| Gene Name |
solute carrier family 6 (neurotransmitter transporter
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6
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| Molecular Note |
A loxP site was inserted upstream of exon 2. An FRT flanked neo cassette with a 3' loxP site was inserted downstream of exon 4. Flp-mediated recombination removed the neo cassette, leaving exons 2, 3, and 4 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
The targeted mutation is on the X chromosome. When maintaining a live colony, homozygous females may be bred with hemizygous males.
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For Research Use Only.
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