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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK C9orf72tm1Lgu/J (Cat. No.: CEMM-07250902) | Inquiry | |
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C9orf72flox+neo (C9orf72 floxed exons 4-5) mice allow Cre recombinase-inducible C9orf72 knock-out. These mice may be useful for studying amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD).
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| B6N.Cg-Mapkapk2tm2.1Yaff/J (Cat. No.: CEMM-07250915) | Inquiry | |
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MK2FL is a floxed allele with loxP sites flanking exon 2 of the MAP kinase-activated protein kinase 2 gene (Mapkapk2). Cre recombinase-mediated removal of the floxed sequence creates a knock-out allele. MK2FL mice may be useful in studying the p38 MAP kinase/MK2 pathway, other checkpoint control pathways, DNA damage response, DNA repair, cell cycle arrest, apoptosis and inflammation-driven tumorigenesis, as well as with other cancer models to study sensitization of tumors to DNA-damaging chemotherapeutics in vivo.
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| STOCK Dctn1tm2.1Cai/J (Cat. No.: CEMM-07250914) | Inquiry | |
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Dctn1LoxP/ mice have loxP sites flanking exons 2-4 of the dynactin 1 gene. Cre recombinase-mediated removal of the floxed sequence results in continued expression of the p135 subunit, but complete loss of p150Glued subunit expression. These mice may be useful in studying the dynactin macromolecular complex in motor neuron disease and other neurodegenerative disorders.
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| B6;129-Fn1tm1Ref/J (Cat. No.: CEMM-07250742) | Inquiry | |
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The Fnfl floxed allele has loxP sites flanking exon 1 of the fibronectin 1 gene. Cre-mediated removal of the floxed sequence creates a null allele. Fnfl mice may be useful in studying extracellular matrix proteins in cardiovascular, cancer and central nervous system.
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| STOCK L3mbtl2tm1.1Haho/J (Cat. No.: CEMM-07250770) | Inquiry | |
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The L3mbtl2 floxed exons 9-14 allele has loxP sites flanking the sequences encoding its three C-terminal malignant brain tumor (MBT) domains. Exposure to Cre recombinase creates a null allele. These mice may be useful in studying early embryonic development, methylated histone-binding and the polycomb repressive complex (e.g., PRC1.6).
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| STOCK Gt(ROSA)26Sortm1(CAG-Clomeleon*)Kjst/J (Cat. No.: CEMM-07251114) | Inquiry | |
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sCLM-floxed KI mice allow Cre-inducible expression of SuperClomeleon, an improved fluorescent fusion protein containing Cerulean and YFP (topaz) that acts as a ratiometric indicator for chloride ions. This strain may be useful for detecting inhibitory synaptic activity in single mouse neurons.
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| STOCK Gt(ROSA)26Sortm1(CAG-Syp/EYFP)Htng/J (Cat. No.: CEMM-07250918) | Inquiry | |
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FSF-LSL-SypYFP (or R26-CAG-FSF-LSL-SypYFP) is a dual-recombinase intersectional allele that has a frt-flanked STOP and loxP-flanked STOP that prevent transcription of a synaptophysin-YFP fusion protein. Exposure to FLP recombinase and Cre recombinase results in YFP expression enriched at the synapse/synaptic vesicle (axonal boutons [terminal and en passant]) of the neuron subtype(s) defined by the overlap of FLP/Cre expression.
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| B6.129S4-Gt(ROSA)26Sortm1(CAG-C9orf72)Lgu/J (Cat. No.: CEMM-07250903) | Inquiry | |
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R26-CAG-LSL-C9orf72 mice allow Cre recombinase-inducible C9ORF72 overexpression. These mice may be useful for studying amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD).
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| STOCK Gt(ROSA)26Sortm6(ACTB-EGFP*, -tdTomato)Luo/J (Cat. No.: CEMM-07250375) | Inquiry | |
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The R26GT allele has a CMV enhancer/chicken beta-actin core promoter-driven "MADM GT" cassette (GFPN-terminus-intron-tdT3MycATG-less) inserted into the Gt(ROSA)26Sor locus on chromosome 6. Like the original MADM system, this "new MADM-6" system provides a tool to generate genetic mosaics in which an individual organism contains somatic cells of different genotypes. This allows Cre or FLP recombinase-induced fluorescent labeling of daughter cells to ascertain lineal relationships and pleiotropic gene function in multicellular organisms. These mice may also be useful in studies of cell differentiation and mitosis.
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| B6.129S1(Cg)-Rai1tm2.1Luo/J (Cat. No.: CEMM-07250715) | Inquiry | |
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The Rai1flox allele has loxP sites flanking exon 3 of the retinoic acid induced 1 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying circuit assembly and neuronal communication in human disorders such as Smith-Magenis syndrome(SMS).
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For Research Use Only.