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STOCK C9orf72tm1Lgu/J
Cat. No.: CEMM-07250902
Common Name: C9orf72 floxed exons 4-5; C9orf72flox+neo; Cre-inducible C9orf72 knock-out
C9orf72flox+neo (C9orf72 floxed exons 4-5) mice allow Cre recombinase-inducible C9orf72 knock-out. These mice may be useful for studying amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
C9orf72tm1Lgu
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
C9orf72
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| Gene Name |
C9orf72
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| Chromosome |
4
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
The targeting vector is designed to insert a loxP site upstream of exon 4, and a FRT neo-frt::loxP cassette downstream of exon 5.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for the floxed allele are viable and fertile with normal breeding, and no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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