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B6N.Cg-Mapkapk2tm2.1Yaff/J

Cat. No.: CEMM-07250915

Common Name: MK2FL
MK2FL is a floxed allele with loxP sites flanking exon 2 of the MAP kinase-activated protein kinase 2 gene (Mapkapk2). Cre recombinase-mediated removal of the floxed sequence creates a knock-out allele. MK2FL mice may be useful in studying the p38 MAP kinase/MK2 pathway, other checkpoint control pathways, DNA damage response, DNA repair, cell cycle arrest, apoptosis and inflammation-driven tumorigenesis, as well as with other cancer models to study sensitization of tumors to DNA-damaging chemotherapeutics in vivo.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Mapkapk2tm2.1Yaff
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Allele Name
targeted mutation 2.1
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Allele Attributes
Conditional ready (e.g. floxed); No functional change
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Gene Symbol
Mapkapk2
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Gene Name
MAP kinase-activated protein kinase 2
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Chromosome
1
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MGI Accession ID
6203066
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Strain of Origin
(C57BL/6 x 129S4/SvJae)F1
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Molecular Note
Exon 2 was floxed and the 5' loxP site is in reverse complement sequence to the 3' loxP site. Flp-mediated recombination removed the selection cassette inserted downstream of the loxP site inserted into intron 2.
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HUSBANDRY
Suggested Controls
C57BL/6NJ
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Breeding Considerations
Mice homozygous for the floxed allele are viable and fertile, with normal fertility and no gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6NJ inbred mice. Alternatively, homozygous mice may be bred together.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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