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STOCK Dctn1tm2.1Cai/J
Cat. No.: CEMM-07250914
Common Name: Dctn1LoxP/
Dctn1LoxP/ mice have loxP sites flanking exons 2-4 of the dynactin 1 gene. Cre recombinase-mediated removal of the floxed sequence results in continued expression of the p135 subunit, but complete loss of p150Glued subunit expression. These mice may be useful in studying the dynactin macromolecular complex in motor neuron disease and other neurodegenerative disorders.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Dctn1tm2.1Cai
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Dctn1
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| Gene Name |
dynactin 1
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
129X1/SvJ
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| Molecular Note |
A targeting vector was designed to insert a loxP-FRT neo-FRT cassette upstream of exon 2, and a loxP site downstream of exon 4 of the dynactin 1 locus (Dctn1) on chromosome 6. Flp-mediated recombination removed the selection cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Mice homozygous for the floxed allele are viable and fertile, with normal fertility and no gross phenotypic or behavioral abnormalities. When maintaining our live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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