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STOCK L3mbtl2tm1.1Haho/J
Cat. No.: CEMM-07250770
Common Name: L3mbtl2 floxed exons 9-14
The L3mbtl2 floxed exons 9-14 allele has loxP sites flanking the sequences encoding its three C-terminal malignant brain tumor (MBT) domains. Exposure to Cre recombinase creates a null allele. These mice may be useful in studying early embryonic development, methylated histone-binding and the polycomb repressive complex (e.g., PRC1.6).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
L3mbtl2tm1.1Haho
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
L3mbtl2
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| Gene Name |
L3MBTL2 polycomb repressive complex 1 subunit
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| Chromosome |
15
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
LoxP sites flanking exons 9-14 and a neomycin gene flanked by FRT sites were inserted via homologous recombination. Flp-mediated recombination removed the neomycin gene.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Mice homozygous for the L3mbtl2 floxed allele are viable and fertile with no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together or to wildtype mice from the colony. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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