Online Inquiry
B6.129S4-Gt(ROSA)26Sortm1(CAG-C9orf72)Lgu/J
Cat. No.: CEMM-07250903
Common Name: R26-CAG-LSL-C9orf72; Cre-inducible C9orf72 overexpression
R26-CAG-LSL-C9orf72 mice allow Cre recombinase-inducible C9ORF72 overexpression. These mice may be useful for studying amyotrophic lateral sclerosis (ALS or Lou Gehrig's disease) and frontotemporal dementia (FTD).
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-C9orf72)Lgu
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Inserted expressed sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
(C57BL/6 x 129S4/SvJae)F1
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| Molecular Note |
The targeting vector is designed to have (from 5' to 3') a CMV-IE enhancer/chicken beta-actin/rabbit beta-globin hybrid promoter (CAG), an FRT site, a loxP site, a transcriptional/translational STOP cassette (with stop codons in all 3 reading frames and a triple polyA signal), a second loxP site, a cDNA sequence encoding the mouse C9orf72 member of C9orf72-SMCR8 complex (C9orf72), a woodchuck hepatitis virus post-transcriptional regulatory element (WPRE), a BGH polyA signal, a second FRT site and a neo cassette. The construct is inserted between exons 1 and 2 of the Gt(ROSA)26Sor locus.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for the R26-CAG-LSL-C9orf72 allele are viable and fertile with normal breeding, and no reported gross physical or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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