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B6.129S1(Cg)-Rai1tm2.1Luo/J
Cat. No.: CEMM-07250715
Common Name: Rai1-flox (Rai1flox)
The Rai1flox allele has loxP sites flanking exon 3 of the retinoic acid induced 1 gene. Removal of the floxed sequence creates a null allele. These mice may be useful in studying circuit assembly and neuronal communication in human disorders such as Smith-Magenis syndrome(SMS).
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Rai1tm2.1Luo
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| Allele Name |
targeted mutation 2.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Rai1
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| Gene Name |
retinoic acid induced 1
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
129S1/Sv
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| Molecular Note |
A targeting vector was designed to insert a FRT5-flanked neo cassette (frt5-pSV40-Neo-pA-frt5) and a loxP site upstream of exon 3, and a loxP downstream of exon 3. Flp-mediated recombination removed the FRT5-flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Mice homozygous for the Rai1flox allele are viable and fertile with no reported gross physical or behavioral abnormalities.When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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