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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6;129S-Atmtm1.1Mmpl/J (Cat. No.: CEMM-07251000) | Inquiry | |
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Atm floxed mice (also known as FX[M]) have loxP sites flanking exon 4 (encoding the N-terminal region) of the Atm gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. Global knock-out mice generated from this floxed allele exhibit many aspects of ataxia-telangiectasia (A-T), including altered immunophenotype and behavioral defects, but without the increased incidence of lymphomas observed in many other models of A-T.
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| B6;129-Tprgltm1.1Tdre/J (Cat. No.: CEMM-07250917) | Inquiry | |
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Moverflox mice have loxP sites flanking exons 1-3 of the Tprgl gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Moverflox mice may be useful in studying synaptic vesicle-associated proteins and neurotransmission, as well as steroid hormone metabolism and liver function.
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| B6(129S6)-P2ry12em1(icre/ERT2)Tda/J (Cat. No.: CEMM-07250992) | Inquiry | |
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P2ry12-CreER mice express a tamoxifen-inducible Cre driven by the endogenous purinergic receptor P2Y, G-protein coupled 12 (P2ry12) promoter. These mice are a Cre-lox tool, allowing inducible Cre recombination in P2ry12-expressing cells/tissues (primarily microglia), and may be useful in studying neuroinflammation, neurodegenerative disease, and immune response.
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| B6.129P2(SJL)-Myliptm1.1Pton/J (Cat. No.: CEMM-07250993) | Inquiry | |
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Idolf/f mice have loxP sites flanking exon 2 of the myosin regulatory light chain interacting protein (Mylip) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Idolf/f mice may be useful in the study of metabolism, obesity, and appetite regulation.
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| B6N.129S-Kat5tm1.1Ge/J (Cat. No.: CEMM-07251005) | Inquiry | |
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TIP60 floxed mice have loxP sites flanking exons 1-9 of the K(lysine) acetyltransferase 5 (Kat5) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These TIP60 floxed mice may be useful in the study of circadian rhythms and related diseases.
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| STOCK Oprk1tm1.1(cre)Sros/J (Cat. No.: CEMM-07251006) | Inquiry | |
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KOR-Cre knock-in/knock-out mice have the endogenous kappa opioid receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Oprk1-expressing cells/tissues (including neurons of the cortex and striatum, retina, lung, liver, and kidney), and may be useful in studying reward, pain, and nociception.
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| STOCK Tacr1tm1.1(cre/ERT2)Sros/J (Cat. No.: CEMM-07251007) | Inquiry | |
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NK1R-CreER knock-in/knock-out mice have the endogenous tachykinin receptor 1 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Tacr-expressing cells/tissues (including neurons of the amygdala, hypothalamus, cortex, and spinal cord), and may be useful in studying Substance P signaling, inflammatory responses, and pain.
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| B6.Cg-Gt(ROSA)26Sortm2(CAG-PA-GFP)Rmpl/J (Cat. No.: CEMM-07251030) | Inquiry | |
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H2B::PaGFP mice carry a photoactivatable histone H2B/green fluorescent protein fusion gene (Pa-GFP) behind a floxed STOP cassette (LSL). In the presence of Cre recombinase and photoactivation, bright nuclear fluorescence can be detected, allowing for the observation and measurement of nuclear and chromatin dynamics in vivo.
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| STOCK Pxntm1.1Cet/J (Cat. No.: CEMM-07251038) | Inquiry | |
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Pxnfl mice have loxP sites flanking exons 2-5 of the paxillin gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Pxnfl mice may be useful in studying brain or mammary gland development.
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| C57BL/6J-Lbhd2em1(cre/ERT2)Fuki/J (Cat. No.: CEMM-07251041) | Inquiry | |
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Lbhd2-CreERT2 knock-in mice have the endogenous LBH domain containing 2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Lbhd2-expressing cells/tissues (including mitral cells of the olfactory bulb), and may be useful in studying neural development and olfactory neurocircuitry.
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For Research Use Only.