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C57BL/6J-Lbhd2em1(cre/ERT2)Fuki/J
Cat. No.: CEMM-07251041
Common Name: Lbhd2-CreERT2
Lbhd2-CreERT2 knock-in mice have the endogenous LBH domain containing 2 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Lbhd2-expressing cells/tissues (including mitral cells of the olfactory bulb), and may be useful in studying neural development and olfactory neurocircuitry.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Lbhd2em1(Cre/ERT2)Fuki
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| Allele Name |
endonuclease-mediated mutation 1
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| Allele Attributes |
Recombinase-expressing; Inducible
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| Gene Symbol |
Lbhd2
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| Gene Name |
LBH domain containing 2
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| Chromosome |
12
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6JJcl
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| Molecular Note |
Using CRISPR/Cas9 technology an IRES enhancer sequence, a CreER(T2) fusion gene, and a rabbit globin polyadenylation (rGpA) termination sequence were inserted immediately downstream of the LBH domain containing 2 locus of the Lbhd2 gene on chromosome 12. The construct was electroporated into C57BL/6JJcl-derived embryonic stem (ES) cells. Correctly targeted ES cells were injected into recipient blastocysts, and chimeric mice were bred with C57BL/6JJcl for germline transmission.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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