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STOCK Oprk1tm1.1(cre)Sros/J
Cat. No.: CEMM-07251006
Common Name: KOR-cre
KOR-Cre knock-in/knock-out mice have the endogenous kappa opioid receptor promoter/enhancer sequences directing expression of Cre recombinase. These mice are a Cre-lox tool allowing Cre recombination in Oprk1-expressing cells/tissues (including neurons of the cortex and striatum, retina, lung, liver, and kidney), and may be useful in studying reward, pain, and nociception.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Oprk1tm1.1(cre)Sros
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Oprk1
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| Gene Name |
opioid receptor
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| Chromosome |
1
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| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
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| Molecular Note |
The coding region of the gene in exon 2 was replaced with a Cre recombinase gene followed by a polyadenylation sequence. An Frt-flanked neomycin selection cassette was inserted at the 3' end, but removed by flp-mediated recmobination in the final allele.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6NJ inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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