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B6;129-Tprgltm1.1Tdre/J
Cat. No.: CEMM-07250917
Common Name: Moverflox
Moverflox mice have loxP sites flanking exons 1-3 of the Tprgl gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Moverflox mice may be useful in studying synaptic vesicle-associated proteins and neurotransmission, as well as steroid hormone metabolism and liver function.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tprgltm1.1Tdre
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Tprgl
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| Gene Name |
transformation related protein 63 regulated like
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| Chromosome |
4
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| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
The targeting vector is designed to insert a loxP site in exon 1 (upstream of the translation start site), and an FRT flanked neo cassette followed by a second loxP site downstream of exon 3. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
B6129SF2/J
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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