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B6.129P2(SJL)-Myliptm1.1Pton/J
Cat. No.: CEMM-07250993
Common Name: Idolf/f
Idolf/f mice have loxP sites flanking exon 2 of the myosin regulatory light chain interacting protein (Mylip) gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Idolf/f mice may be useful in the study of metabolism, obesity, and appetite regulation.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Myliptm1.1Pton
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Mylip
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| Gene Name |
myosin regulatory light chain interacting protein
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| Chromosome |
13
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| MGI Accession ID | show more close |
| Strain of Origin |
129P2/OlaHsd
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| Molecular Note |
A cassette containing (5' to 3') a lox71 site, FRT site, loxP site, engrailed 2 splice acceptor, betal gal, neo resistance gene, polyadenylation sequence, and a second FRT site. An additional loxP site was inserted downstream of exon 2. Flp-mediated recombination removed the FRT flanked neo cassette leaving leaving only exon 2 flanked by an upstream lox71 site and a downstream loxP site.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6J inbred mice. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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