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B6;129S-Atmtm1.1Mmpl/J

Cat. No.: CEMM-07251000

Common Name: FX[M]
Atm floxed mice (also known as FX[M]) have loxP sites flanking exon 4 (encoding the N-terminal region) of the Atm gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. Global knock-out mice generated from this floxed allele exhibit many aspects of ataxia-telangiectasia (A-T), including altered immunophenotype and behavioral defects, but without the increased incidence of lymphomas observed in many other models of A-T.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Atmtm1.1Mmpl
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Allele Name
targeted mutation 1.1
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Allele Attributes
Null/Knockout
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Gene Symbol
Atm
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Gene Name
ataxia telangiectasia mutated
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Chromosome
9
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MGI Accession ID
5806239
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Strain of Origin
129S6/SvEvTac
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Molecular Note
Two loxP sites were inserted into the introns surrounding to exon 4. Flp-mediated recombination removed the FRT flanked neomycin resistance cassette inserted into intron 3. Cre-mediated recombination removed exon 4. This allele is predicted to cause a frameshift mutation through the splicing of exon 3 to exon 5. Western blot analysis confirmed the absence of protein expression in fibroblasts.
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HUSBANDRY
Suggested Controls
B6129SF2/J
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Breeding Considerations
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together or to wildtype mice from the colony. Alternatively, homozygous mice may be bred together.
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For Research Use Only.
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