Online Inquiry
STOCK Tacr1tm1.1(cre/ERT2)Sros/J
Cat. No.: CEMM-07251007
Common Name: NK1R-CreER
NK1R-CreER knock-in/knock-out mice have the endogenous tachykinin receptor 1 promoter/enhancer sequences directing expression of tamoxifen-inducible Cre recombinase. These mice are a Cre-lox tool allowing inducible Cre recombination in Tacr-expressing cells/tissues (including neurons of the amygdala, hypothalamus, cortex, and spinal cord), and may be useful in studying Substance P signaling, inflammatory responses, and pain.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tacr1tm1.1(cre/ERT2)Sros
show more
close
|
| Allele Name |
targeted mutation 1.1
show more
close
|
| Allele Attributes |
Recombinase-expressing; Inducible; Null/Knockout
show more
close
|
| Gene Symbol |
Tacr1
show more
close
|
| Gene Name |
tachykinin receptor 1
show more
close
|
| Chromosome |
6
show more
close
|
| MGI Accession ID | show more close |
| Strain of Origin |
129S4/SvJae
show more
close
|
| Molecular Note |
The coding region of Tacr1 in exon2 was replaced by a Cre/ERT2 cassette and a loxP-flanked neo selection cassette by homologous recombination in ES cells. Correctly targeted ES cell clones were injected into C57BL/6 blastocysts. The neo-cassette was deleted by Cre-mediated excision.
show more
close
|
| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6NJ
show more
close
|
| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to C57BL/6NJ inbred mice. Alternatively, homozygous mice may be bred together.
show more
close
|
| Breeding Strategy |
Homozygote x Homozygote
show more
close
|
For Research Use Only.
Related Products