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STOCK Pxntm1.1Cet/J
Cat. No.: CEMM-07251038
Common Name: Pxnfl
Pxnfl mice have loxP sites flanking exons 2-5 of the paxillin gene. Exposure to Cre recombinase removes the floxed sequence - creating a null allele. These Pxnfl mice may be useful in studying brain or mammary gland development.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pxntm1.1Cet
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Pxn
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| Gene Name |
paxillin
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| Chromosome |
5
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6 x 129S/Sv
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| Molecular Note |
The targeting vector is designed to insert a loxP site upstream of exon 2, and a second loxP site followed by an FRT flanked PGK-neo cassette just downstream of exon 5. Flp-mediated recombination removed the FRT flanked neo cassette leaving exons 2 through 5 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
FVB/NJ
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| Breeding Considerations |
Both heterozygous and homozygous mice are viable and fertile with normal breeding, and no reported gross phenotypic or behavioral abnormalities. When maintaining a live colony, heterozygous mice may be bred together, to wildtype mice from the colony or to FVB/NJ inbred mice. Alternatively, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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