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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.129-Optntm1.1Htse/J (Cat. No.: CEMM-07251096) | Inquiry | |
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Exon 1 of the mouse Optn gene is flanked by loxP sites in these Optnflox conditional mutant mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in a range of research areas including glaucoma, amyotrophic lateral sclerosis (ALS), and Paget's Disease, as well as Alzheimer's, Parkinson's and Huntington's diseases.
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| STOCK Adgrl1tm2.1Sud/J (Cat. No.: CEMM-07251010) | Inquiry | |
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Myc-Lphn1 cKI mice express Myc-tagged mouse ADGRL1 (adhesion G protein-coupled receptor L1; also called LPHN1) protein. Cre recombinase-mediated excision of floxed exon 2 results in a knock-out allele.
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| C57BL/6-Vipr2em1Litt/J (Cat. No.: CEMM-07251014) | Inquiry | |
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Exons 3 and 4 of the mouse Vipr2 (vasoactive intestinal peptide receptor 2) gene are flanked by loxP sites in these CRISPR-generated Vipr2fl mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele.
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| C57BL/6-Scn2atm1.1Csbd/J (Cat. No.: CEMM-07251025) | Inquiry | |
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Scn2af/+ conditional mutant mice carry a floxed allele in which exons 4-6 of the mouse Scn2a (sodium channel, voltage-gated, type II, alpha) gene are flanked by loxP sites. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of neuronal synaptic transmission.
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| STOCK Arf1tm1c(EUCOMM)Wtsi/HousJ (Cat. No.: CEMM-07251090) | Inquiry | |
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Exons 2-5 of the mouse Arf1 gene are flanked by loxP sites in these Arf1fl mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of lipid metabolism, cancer, and neurodegeneration.
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| STOCK Gcktm1.1Arte/J (Cat. No.: CEMM-07251095) | Inquiry | |
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Exons 5 and 6 of the mouse Gck (glucokinase) gene are flanked by loxP sites in this Gckf allele. Cre recombinase-mediated excision of the floxed region results in a gene knock-out useful in studies of insulin secretion, glucosensing, adiposity, and feeding behavior.
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| C57BL/6-Gt(ROSA)26Sorem1(CAG-Kcnq2*/EGFP)Hjch/J (Cat. No.: CEMM-07251124) | Inquiry | |
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Kcnq2‐M547Vfl mice carry a floxed‐STOP cassette upstream of a Kcnq2 M547V‐ires‐EGFP cassette placed in the Gt(ROSA)26Sor gene. Upon excision of the floxed‐STOP cassette by Cre recombinase, this line expresses murine Kcnq2 gene containing the epileptic encephalopathy mutation M547V and enhanced green fluorescent protein (EGFP).
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| B6(Cg)-Rhot1tm2.1Jmsu/J (Cat. No.: CEMM-07250847) | Inquiry | |
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Exon 2 of the mouse Rhot1 (Miro1) gene is flanked by loxP sites in this Miro1F conditional mutant strain. Cre-mediated excision of the floxed region results in a knock-out allele useful in studies of mitochondria and motor neuron disease.
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| C57BL/6J-Gt(ROSA)26Sortm1(CAG-Saa1, -EGFP)Litt/J (Cat. No.: CEMM-07251031) | Inquiry | |
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LoxP-STOP-loxP-SAA1 (also called LSL-SAA1) knock-in mice carry a conditional mutant allele in which Saa1 (serum amyloid A 1) and IRES-EGFP are over-expressed from a CAG promoter upon cre recombinase-mediated excision of a loxP-flanked neomycin/Stop cassette. This strain has been useful in studies of Th17 cell responses, inflammation, and autoimmunity. The functionality of the EGFP reporter has not been assessed.
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| 129S-Ndel1tm2Shr/AwbJ (Cat. No.: CEMM-07250625) | Inquiry | |
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The Ndel1cko(IV) hypomorphic conditional knock-out allele (also called Ndel1cko or Ndel1hc) acts as a hypomorph before exposure to Cre recombinase, and can be converted to a null allele by cre-deletion of exon 4. These mice are useful in studying normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner.
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For Research Use Only.