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C57BL/6-Scn2atm1.1Csbd/J
Cat. No.: CEMM-07251025
Common Name: Scn2af
Scn2af/+ conditional mutant mice carry a floxed allele in which exons 4-6 of the mouse Scn2a (sodium channel, voltage-gated, type II, alpha) gene are flanked by loxP sites. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in studies of neuronal synaptic transmission.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Scn2atm1.1Csbd
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Scn2a
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| Gene Name |
sodium channel
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
An FRT site, EGFP, loxP site, neomycin selection gene, FRT site and loxP site were inserted upstream of exon 4 and a third loxP site was inserted downstream of exon 6. Flp-mediated recombination removed the EGFP and neomycin genes, leaving exons 4-6 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
Wild-type from the colony
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Homozygote x Homozygote
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For Research Use Only.
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