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STOCK Gcktm1.1Arte/J
Cat. No.: CEMM-07251095
Common Name: Gcklox
Exons 5 and 6 of the mouse Gck (glucokinase) gene are flanked by loxP sites in this Gckf allele. Cre recombinase-mediated excision of the floxed region results in a gene knock-out useful in studies of insulin secretion, glucosensing, adiposity, and feeding behavior.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gcktm1.1Arte
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Gck
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| Gene Name |
glucokinase
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Strain of Origin |
Not Specified
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| Molecular Note |
Exons 5 and 6 were flanked by loxP sites and a FRT flanked positive selection marker puromycin was inserted in intron 4. Flp-mediated recombination removed the puromycin gene.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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