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129S-Ndel1tm2Shr/AwbJ

Cat. No.: CEMM-07250625

Common Name: Ndel1cko(IV) hypomorphic conditional knock-out
The Ndel1cko(IV) hypomorphic conditional knock-out allele (also called Ndel1cko or Ndel1hc) acts as a hypomorph before exposure to Cre recombinase, and can be converted to a null allele by cre-deletion of exon 4. These mice are useful in studying normal cortical neuronal migration, neurite outgrowth, and function of the microtubule organizing center in a dose-dependent manner.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Ndel1tm2Shr
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Allele Name
targeted mutation 2
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Allele Attributes
Conditional ready (e.g. floxed); Hypomorph
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Gene Symbol
Ndel1
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Gene Name
nudE neurodevelopment protein 1 like 1
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Chromosome
11
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MGI Accession ID
3589467
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Strain of Origin
129S6/SvEvTac
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Molecular Note
A targeting vector was designed to insert loxP sites to flank exon IV. A floxed neo was included in the vector. This allele acts as a hypomorph with expression suppressed to 30%.
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HUSBANDRY
Suggested Controls
Wild-type from the colony
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Breeding Considerations
Heterozygous and homozygous mice are both viable and fertile. When maintaining a live colony, heterozygous mice may be bred together or to wildtype mice from the colony. Homozygous mice may also be bred together.
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Breeding Strategy
Heterozygote x Heterozygote
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For Research Use Only.
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