Online Inquiry
C57BL/6J-Gt(ROSA)26Sortm1(CAG-Saa1, -EGFP)Litt/J
Cat. No.: CEMM-07251031
Common Name: LoxP-STOP-loxP-SAA1; LSL-SAA1
LoxP-STOP-loxP-SAA1 (also called LSL-SAA1) knock-in mice carry a conditional mutant allele in which Saa1 (serum amyloid A 1) and IRES-EGFP are over-expressed from a CAG promoter upon cre recombinase-mediated excision of a loxP-flanked neomycin/Stop cassette. This strain has been useful in studies of Th17 cell responses, inflammation, and autoimmunity. The functionality of the EGFP reporter has not been assessed.
Inquiry
| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Gt(ROSA)26Sortm1(CAG-Saa1,-EGFP)Litt
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); Reporter; Inserted expressed sequence
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| Gene Symbol |
Gt(ROSA)26Sor
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| Gene Name |
gene trap ROSA 26
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| Chromosome |
6
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| MGI Accession ID | show more close |
| Strain of Origin |
C57BL/6J
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| Molecular Note |
A CAG-loxP-Neo-STOP-loxP-Saa1-FRT IRES-EGFP-FRT pA cassette was cloned into CTV vector, and introduced to intron 1 of the mouse Gt(ROSA)26Sor locus.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable, fertile, healthy, and born at Mendelian ratios.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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