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B6.129-Optntm1.1Htse/J
Cat. No.: CEMM-07251096
Common Name: Optnflox
Exon 1 of the mouse Optn gene is flanked by loxP sites in these Optnflox conditional mutant mice. Cre recombinase-mediated excision of the floxed region results in a knock-out allele useful in a range of research areas including glaucoma, amyotrophic lateral sclerosis (ALS), and Paget's Disease, as well as Alzheimer's, Parkinson's and Huntington's diseases.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Optntm1.1Htse
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Optn
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| Gene Name |
optineurin
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A loxP site was introduced 5' of exon 1 and an FRT neomycin-FRT loxP cassette was placed 3' of exon 1. FLP-mediated recombination removed the neomycin cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
Heterozygous and homozygous floxed mice are viable and fertile.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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