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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Igs2tm2(ACTB-tdTomato, -EGFP)Luo Trp53tm1Tyj Nf1tm1Par/J (Cat. No.: CEMM-07250353) | Inquiry | |
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The MADM-TG, p53KO, NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADM strain, and to a Cre recombinase expressing strain.
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| STOCK Notch1tm2Rko Notch2tm3Grid Gt(ROSA)26Sortm9(CAG-tdTomato)Hze Tg(KRT5-cre/ERT2)2Ipc/JeswJ (Cat. No.: CEMM-07250830) | Inquiry | |
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K5CreER;N1fl;N2fl;Ai9 mice (or K5-fl(N1/N2)-Ai9) are quadruple mutant animals with tamoxifen-inducible Cre recombinase expression directed to basal epithelial cell populations - resulting in Notch1/Notch2 knock-out and robust tdTomato fluorescence. These mice allow inducible genetic manipulations for studying Notch pathway disruption in epithelial tissues (e.g., epidermis, salivary gland, digestive tract, peripheral olfactory system) as well as UV-light skin damage and cancer biomarkers.
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| B6;129-Gt(ROSA)26Sortm1(rtTA*M2)Jae Col1a1tm1(tetO-cre)Haho/J (Cat. No.: CEMM-07250431) | Inquiry | |
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These double mutant R26-M2rtTA::TetOP-Cre mice utilize the rtTA/tetO (tet-on/TRE) system to allow highly-efficient, doxycycline-inducible Cre recombinase expression in hematopoietic stem cells. These mice harbor the R26M2rtTA targeted mutation (an optimized form of reverse tetracycline controlled transactivator [rtTA-M2] downstream of the Gt(ROSA)26Sor promoter) and the Col1a1TetOP-Cre targeted mutation (a tetracycline responsive element-driven Cre recombinase targeted to the collagen type I alpha 1 locus).
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| B6;129-Gt(ROSA)26Sortm1(CAG-COP4*E123T*H134R, -tdTomato)Gfng/J (Cat. No.: CEMM-07250337) | Inquiry | |
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The R26-CAG-LSL-2XChETA-tdTomato reporter allele is designed to express two individual proteins following exposure to Cre recombinase; the ChR2-E123T accelerated (ChETA)/H134R variant of channelrhodopsin-2 and tdTomato fluorescent protein gene. When used with neuron-specific Cre recombinase expressing strains, the double mutant mice can be used in optogenetic studies and visualization of whole neurons.
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| B6.Cg-Tg(Plp1-cre/ERT)3Pop/J (Cat. No.: CEMM-07250031) | Inquiry | |
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These transgenic mice have a tamoxifen inducible Cre-mediated recombination system driven by the mouse Plp1, proteolipid protein (myelin) 1 promoter. When crossed with a strain containing a loxP site flanked sequence of interest, the offspring are useful for generating tamoxifen-induced, Cre-mediated targeted deletions. Tamoxifen administration allows for ablation of predetermined genes in oligodendrocytes and Schwann cells, and will also induce Cre recombination in developing embryos of treated mothers and in cultured cells derived from transgenic mice.
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| B6.129-Otx1tm4(cre)Asim/J (Cat. No.: CEMM-07250030) | Inquiry | |
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These mice express Cre recombinase directed by endogenous Otx1 promoter/enhancer elements. When induced, Cre recombinase activity is observed in the embryonic lateral midbrain and presumptive alar-basal plate boundary.
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| 129(Cg)-Foxg1tm1(cre)Skm/J (Cat. No.: CEMM-07250015) | Inquiry | |
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Foxg1-Cre knock-in/knock-out mice express Cre recombinase from the endogenous Foxg1 locus specifically in the telencephalon and discrete head structures. Of note, this Foxg1-Cre knock-in/knock-out allele is available on a congenic 129 genetic background and a congenic C57BL/6J genetic background. In contrast, the Foxg1-IRES-Cre knock-in allele retains endogenous Foxg1 expression.
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| B6.129P2(Cg)-Foxg1tm1(cre)Skm/J (Cat. No.: CEMM-07250039) | Inquiry | |
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mice express Cre recombinase from the endogenous Foxg1 locus specifically in the telencephalon and discrete head structures. Heterozygotes exhibit disruption of forebrain development, resulting in reduction in the volume of the neocortex, hippocampus and striatum. When crossed with a strain containing a floxed gene of interest, Cre-mediated recombination is observed in the telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. These mice may be useful in studies of telencephalic development.
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| STOCK Glstm1Sray/J (Cat. No.: CEMM-07250387) | Inquiry | |
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A floxed STOP cassette disrupts exon 1 of the Gls gene in this strain. Homozygotes exhibit abnormal goal-directed behavior, die within 36 hours of birth. These mice may have application in studies related to cellular energy metabolism.
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| B6;129-Pax3tm1(cre)Joe/J (Cat. No.: CEMM-07250026) | Inquiry | |
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Cre recombinase expression is detected in the dorsal neural tube and somites of early embryos and in neural crest and somite derivatives of later gestation embryos. This knock-in mutant mouse strain represents a model that may be useful in studies of development and lineage mapping of neural crest and somite derivatives
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For Research Use Only.