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B6.129-Otx1tm4(cre)Asim/J
Cat. No.: CEMM-07250030
Common Name: Otx1Cre
These mice express Cre recombinase directed by endogenous Otx1 promoter/enhancer elements. When induced, Cre recombinase activity is observed in the embryonic lateral midbrain and presumptive alar-basal plate boundary.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Otx1tm4(cre)Asim
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| Allele Name |
targeted mutation 4
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Otx1
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| Gene Name |
orthodenticle homeobox 1
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| Chromosome |
11
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
lateral midbrain of embryonic day 10.5 aged embryos and in the presumptive alar-basal plate boundary of embryonic day 12.5 aged embryos
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
Exon 2 and part of exon 1 were deleted and replaced with a Cre-neo cassette via homologous recombination, resulting in Cre expression under Otx1 regulatory elements.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J Wild-type from the colony
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| Breeding Considerations |
When maintaining a live colony, these mice are bred as heterozygotes due to homozygous perinatal lethality.
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For Research Use Only.
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