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STOCK Igs2tm2(ACTB-tdTomato, -EGFP)Luo Trp53tm1Tyj Nf1tm1Par/J
Cat. No.: CEMM-07250353
Common Name: MADM-TG; p53KO; NF1flox
The MADM-TG, p53KO, NF1-flox strain may be used as a genetic mosaicism model for different types of cancers when bred to the companion MADM strain, and to a Cre recombinase expressing strain.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nf1tm1Par
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Nf1
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| Gene Name |
neurofibromin 1
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| Chromosome |
11
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| MGI Accession ID | show more close |
| Site of Expression |
When mice carrying this allele are mated to a Synapsin I promoter driven Cre transgenic mouse strain, NF1 function is abated in most differentiated neuronal populations, resulting in abnormal development of the cerebral cortex.
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| Strain of Origin |
(129X1/SvJ x 129S1/Sv)F1-Kitl+
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| Molecular Note |
A loxP-neomycin selection cassette was inserted into intron 30 and a single loxP site was inserted into intron 32.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, mice homozygous for the Tg(ACTB-tdTomato, -EGFP)11Luo transgene, heterozygous for Trp53tm1Tyj allele, and homozygous for the Nf1tm1Par allele may be bred to mice homozygous for the Tg(ACTB-tdTomato, -EGFP)11Luo transgene, wildtype at the Trp53 locus, and homozygous for the Nf1tm1Par allele.
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For Research Use Only.
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