Products

Online Inquiry

129(Cg)-Foxg1tm1(cre)Skm/J

Cat. No.: CEMM-07250015

Common Name: Foxg1-Cre knock-in/knock-out
Foxg1-Cre knock-in/knock-out mice express Cre recombinase from the endogenous Foxg1 locus specifically in the telencephalon and discrete head structures. Of note, this Foxg1-Cre knock-in/knock-out allele is available on a congenic 129 genetic background and a congenic C57BL/6J genetic background. In contrast, the Foxg1-IRES-Cre knock-in allele retains endogenous Foxg1 expression.
Inquiry
Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Foxg1tm1(cre)Skm
show more close
Allele Name
targeted mutation 1
show more close
Allele Attributes
Recombinase-expressing; Null/Knockout
show more close
Gene Symbol
Foxg1
show more close
Gene Name
forkhead box G1
show more close
Chromosome
12
show more close
Expressed Genes
Cre, Cre recombinase, bacteriophage P1
show more close
MGI Accession ID
1932522
show more close
Site of Expression
Telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches
show more close
Strain of Origin
129P2/OlaHsd-Hprtb-m3
show more close
Molecular Note
Most of the coding region was replaced with a Cre gene and a neomycin cassette. The Cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches.
show more close
HUSBANDRY
Suggested Controls
Wild-type from the colony
show more close
Breeding Considerations
When maintaining a live colony, these mice are bred as heterozygotes. For Cre-lox experiments and to avoid/minimize germline deletion of the floxed allele, researchers may consider breeding Foxg1-Cre females to floxed males.
show more close
For Research Use Only.
Related Products