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B6.129P2(Cg)-Foxg1tm1(cre)Skm/J

Cat. No.: CEMM-07250039

Common Name: Foxg1-Cre knock-in/knock-out
mice express Cre recombinase from the endogenous Foxg1 locus specifically in the telencephalon and discrete head structures. Heterozygotes exhibit disruption of forebrain development, resulting in reduction in the volume of the neocortex, hippocampus and striatum. When crossed with a strain containing a floxed gene of interest, Cre-mediated recombination is observed in the telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches. These mice may be useful in studies of telencephalic development.
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Status Live Mouse
Frozen Embryo
Age 4 weeks
12 weeks
Customized Age
Sex Male
Female
GENETICS
Allele Symbol
Foxg1tm1(cre)Skm
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Allele Name
targeted mutation 1
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Allele Attributes
Recombinase-expressing; Null/Knockout
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Gene Symbol
Foxg1
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Gene Name
forkhead box G1
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Chromosome
12
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Expressed Genes
Cre, Cre recombinase, bacteriophage P1
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MGI Accession ID
1932522
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Site of Expression
Telencephalon, anterior optic vesicle (developing lens and retina), otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches
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Strain of Origin
129P2/OlaHsd-Hprtb-m3
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Molecular Note
Most of the coding region was replaced with a Cre gene and a neomycin cassette. The Cre gene sequence was fused in-frame following the first 13 codons of the gene. The endogenous promoter is active in telencephalon, anterior optic vesicle, otic vesicle, facial and head ectoderm, olfactory epithelium, mid-hindbrain junction and pharyngeal pouches.
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HUSBANDRY
Suggested Controls
C57BL/6J Wild-type from the colony
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Breeding Considerations
When maintaining a live colony, these mice are bred as heterozygotes. For Cre-lox experiments and to avoid/minimize germline deletion of the floxed allele, researchers may consider breeding Foxg1-Cre females to floxed males.
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Breeding Strategy
Wild-type x Heterozygote; Heterozygote x Wild-type
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For Research Use Only.
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