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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6.Cg-Atoh1em1(cre)Zyliu/J (Cat. No.: CEMM-07251094) | Inquiry | |
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Atoh13*HA-P2A-Cre knock-in mice carry a CRISPR/Cas9 generated insertion of three HA tags and Cre recombinase just upstream of the stop codon of the Atoh1 gene. These mice are useful for lineage tracing, cell sorting, and gene manipulation of multiple cell types including cochlear hair cells (HCs).
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| B6(SJL)-Gabra2tm2.1Uru/J (Cat. No.: CEMM-07251097) | Inquiry | |
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The α2fl mice have loxP sites flanking exon 5 of the Gabra2 gene. These mice may be useful for studying physiologic and therapeutic properties of GABAA α-subunits in such diseases as epilepsy or substance abuse disorders.
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| STOCK Gt(ROSA)26Sortm10.1(CAG-birA*, -mKate2)Amc/J (Cat. No.: CEMM-07251111) | Inquiry | |
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R26 BirA*G3 knock-in mice have a CAG promoter controlling the Cre-inducible expression of a myc-tagged endoplasmic reticulum-directed promiscuous biotin ligase sequence, BirA*G3-ER. Cre-mediated recombination results in the excision of a floxed GFP sequence, enabling the tissue and time-dependent expression of BirA*G3 and mKate2. This is a tool for the isolation and purification of proteins and protein complexes trafficking through the secretory pathway upon biotin administration.
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| B6;C3-Oxtrem2(icre)Yinn/J (Cat. No.: CEMM-07251117) | Inquiry | |
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Oxtr1xPA-iCre knock-in mice express a PA-tag and a codon improved cre recombinase (icre) under direction of the endogenous oxytocin receptor (Oxtr) promoter in brain regions. This mouse strain could be useful for manipulation of oxytocin receptor-expressing cells.
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| B6;C3-Oxtrem4(icre/ERT2)Yinn/J (Cat. No.: CEMM-07251118) | Inquiry | |
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Oxtr3xHA-iCreERT2 knock-in mice express a 3xHA-tag and icre/ERT2 under direction of the endogenous oxytocin receptor (Oxtr) promoter in brain regions. This mouse strain could be useful for oxytocin receptor visualization and manipulation.
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| B6;129S4-Cdh8tm2c(KOMP)Wtsi/DlbeJ (Cat. No.: CEMM-07251119) | Inquiry | |
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Cdh8FL/FL mice have loxP sites flanking exon 3 of the cadherin 8 gene, making them useful for studying synaptic adhesion, axon outgrowth and guidance.
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| B6.Cg-H2-K1em1Tyj/AjgrJ (Cat. No.: CEMM-07251126) | Inquiry | |
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KbStrep knock-in mice have an inverted StrepTagII, flanked by two pairs of inward-facing heterospecific Lox sites, inserted into intron 1 of the H2-K1 gene. Upon cre induction, recombination of the Lox sites results in the inversion of the StrepTagII into the correct transcriptional orientation. These mice may be useful for the selective purification of MHC-I peptide antigens from cell type(s) of interest from intact tissues.
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| C57BL/6J-Grm3tm1.1Conn/J (Cat. No.: CEMM-07251129) | Inquiry | |
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Grm3Fl floxed mice have loxP sites flanking exon 3 of the Grm3 gene. These mice may be useful when studying the role of mGlu3 receptors in the regulation of synaptic plasticity and cognition.
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| C57BL/6-Nrxn1tm5Sud/J (Cat. No.: CEMM-07250605) | Inquiry | |
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Nrxn1flox mice may be useful for generating tissue specific deletions of neurexin I in neuronal cells.
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| STOCK Tor1atm4.1Wtd/J (Cat. No.: CEMM-07250654) | Inquiry | |
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Tor1aswap mutant mice possess loxP sites flanking exon 5 of the Tor1a gene, and also contains a downstream mutant exon 5. Removal of the floxed wild type exons allows expression of the mutant exon 5. This strain may be useful for studying the autosomal dominant disorder, DYT1 dystonia.
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For Research Use Only.