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STOCK Tor1atm4.1Wtd/J
Cat. No.: CEMM-07250654
Common Name: Tor1aswap
Tor1aswap mutant mice possess loxP sites flanking exon 5 of the Tor1a gene, and also contains a downstream mutant exon 5. Removal of the floxed wild type exons allows expression of the mutant exon 5. This strain may be useful for studying the autosomal dominant disorder, DYT1 dystonia.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tor1atm4.1Wtd
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| Allele Name |
targeted mutation 4.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Tor1a
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| Gene Name |
torsin family 1
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S/SvEv x C57BL/6
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| Molecular Note |
A targeting vector was designed to insert a loxP site upstream of exon 5 followed by a FRT flanked neomycin resistance (neo) cassette, and a second loxP site downstream of exon 5 of the gene. A mutant exon 5, with a glutamic acid residue deletion, was inserted downstream of the neo cassette. Flp-mediated recombination removed the FRT flanked neo cassette.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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