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    Mouse Models

    Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.

    For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.

    • Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
    • Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
    • Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
    • Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.

    If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.

    Our Mouse Models

    Reporter Mouse
    Floxed Mouse
    Recombinase-expressing Mouse
    Inducible Mouse
    B6.129(FVB)-Gt(ROSA)26Sortm1(CAG-birA, -EGFP)Joez/J (Cat. No.: CEMM-07250803) Inquiry
    cBirA mice are designed to express BirA (biotin ligase) and EGFP following exposure to Cre recombinase. This is a tool for the isolation and purification of proteins and protein complexes from tissues.
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    B6.129(Cg)-Sgk1tm1.1Palm/J (Cat. No.: CEMM-07251037) Inquiry
    Sgk1flox mice have loxP sites flanking exons 1-5 of the serum/glucocorticoid regulated kinase 1 (Sgk1) gene. This strain is useful for studying renal physiology, insulin sensitivity, mitochondrial metabolism, and autophagy, as well as the mediation of reward behavior due to chronic drug abuse.
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    B6.129-Nr1h3tm1.1Djm/J (Cat. No.: CEMM-07251065) Inquiry
    Lxrafl/fl floxed mice have loxP sites flanking exons 4-5 of the Nr1h3 gene. This strain is useful for studying lipid metabolism and cholesterol homeostasis.
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    B6.129S4-Xisttm2Jae/GribJ (Cat. No.: CEMM-07251116) Inquiry
    Xist2lox/2lox floxed mice have loxP sites flanking exons 1-3, as well as 5 kb of the proximal promoter, of the X-linked Xist gene. These mice may be useful when studying X chromosome inactivation and reactivation.
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    STOCK Gt(ROSA)26Sortm1(DTA)Jpmb/J (Cat. No.: CEMM-07250046) Inquiry
    ROSA26-eGFP-DTA mice have a loxP-flanked STOP cassette preventing expression of diphtheria toxin fragment A (DTA). Exposure to Cre recombinase removes the lox-stop fragment - resulting in ablation of the cre-expressing cells. These ROSA26-eGFP-DTA mice are useful for Cre-inducible deletion of specific groups of cells.C57BL/6J-congenic ROSA26-eGFP-DTA mice are available as.
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    B6.Cg-Cacna1ftm1.2Sdie/J (Cat. No.: CEMM-07250365) Inquiry
    These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
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    B6;129S7-Grprtm1Zfc/J (Cat. No.: CEMM-07250944) Inquiry
    GrprF mice possess loxP sites flanking exon 2 of the X-linked gastrin releasing peptide receptor (Grpr) gene. These floxed mice are useful when studying contagious itch behavior.
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    B6.129-Cdkl5tm1.2Joez/J (Cat. No.: CEMM-07250806) Inquiry
    Cdkl5 floxed mice contain loxP sites flanking exon 6 the X-linked cyclin-dependent kinase-like 5 (Cdkl5) gene, making them useful when studying neurodevelopmental disorders such as Rett syndrome, autism spectrum disorders, and early infantile epileptic encephalopathy.
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    129S.B6(SJL)-Fgf13tm1c(EUCOMM)Wtsi/GolJ (Cat. No.: CEMM-07251050) Inquiry
    Fhf2fl/fl floxed mice have loxP sites flanking exon 3 of the X-linked fibroblast growth factor 13 (Fgf13) gene. These mice are useful for studying the effects of sodium channel inactivation on cardiac conduction failure.
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    C57BL/6-Camk2atm1Vyb/J (Cat. No.: CEMM-07250054) Inquiry
    These floxed mutant mice possess loxP sites flanking exon 2 of the Camk2a gene. This strain may be useful for generating conditional mutations in applications related to neurological studies.
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    For Research Use Only.