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B6.129(Cg)-Sgk1tm1.1Palm/J
Cat. No.: CEMM-07251037
Common Name: SGK1 floxed
Sgk1flox mice have loxP sites flanking exons 1-5 of the serum/glucocorticoid regulated kinase 1 (Sgk1) gene. This strain is useful for studying renal physiology, insulin sensitivity, mitochondrial metabolism, and autophagy, as well as the mediation of reward behavior due to chronic drug abuse.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Sgk1tm1.1Palm
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| Allele Name |
targeted mutation 1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Sgk1
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| Gene Name |
serum/glucocorticoid regulated kinase 1
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| Chromosome |
10
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A loxP site was inserted into the BsaHI site in intron 1, and a loxP site and a FRT flanked neomycin cassette was inserted into the XcmI site in intron 6. Flp-mediated recombination removed the neo cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygotes may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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