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B6.129-Nr1h3tm1.1Djm/J
Cat. No.: CEMM-07251065
Common Name: Lxrafl
Lxrafl/fl floxed mice have loxP sites flanking exons 4-5 of the Nr1h3 gene. This strain is useful for studying lipid metabolism and cholesterol homeostasis.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Nr1h3tm1.1Djm
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Nr1h3
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| Gene Name |
nuclear receptor subfamily 1
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S/SvEv
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| Molecular Note |
A loxP site was inserted upstream of exon 4. An FRT flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exons 4 and 5 floxed.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygotes may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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