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B6.129-Cdkl5tm1.2Joez/J
Cat. No.: CEMM-07250806
Common Name: Cdkl5 floxed
Cdkl5 floxed mice contain loxP sites flanking exon 6 the X-linked cyclin-dependent kinase-like 5 (Cdkl5) gene, making them useful when studying neurodevelopmental disorders such as Rett syndrome, autism spectrum disorders, and early infantile epileptic encephalopathy.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Cdkl5tm1.2Joez
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Cdkl5
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| Gene Name |
cyclin-dependent kinase-like 5
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
129
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| Molecular Note |
A floxed neo cassette was inserted upstream of exon 6. A loxP site was inserted downstream of exon 6. Cre-mediated recombination removed the neo cassette, but not exon 6.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, homozygous females may be bred to hemizygous males. Mutation is X-linked.
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| Breeding Strategy |
Homozygote x Hemizygote
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For Research Use Only.
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