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B6.Cg-Cacna1ftm1.2Sdie/J
Cat. No.: CEMM-07250365
These mice carry the I756T point mutation in exon 17, and loxP sites flanking exons 14 through 17, of the Cacna1f (calcium channel, voltage-dependent, alpha 1F subunit). This mutant mouse strain may be useful in studies of calcium channelopathies, an inherited retinal disorder, photoreceptor electrophysiology, and the role of the Cav1.4 channel in survival of naive T cells.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Cacna1ftm1.2Sdie
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| Allele Name |
targeted mutation 1.2
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| Allele Attributes |
Conditional ready (e.g. floxed); No functional change
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| Gene Symbol |
Cacna1f
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| Gene Name |
calcium channel
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| Chromosome |
X
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| MGI Accession ID | show more close |
| Strain of Origin |
B6.Cg-Thy1a
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| Molecular Note |
Cacna1ftm1Sdie mice were crossed with FLP recombinase-expressing mice to remove the neomycin selection cassette. This allele retains the I756T point mutation in exon 17 and the loxP sites flanking exons 14 through 17.
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| HUSBANDRY | |
|---|---|
| Breeding Considerations |
When maintaining a live colony, homozygous females may be bred to hemizygous males(mutation is X-linked).
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For Research Use Only.
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