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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| STOCK Tg(Htr6-cre/ERT2)NIDA108Htz/J (Cat. No.: CEMM-07250800) | Inquiry | |
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These transgenic BAC mice express tamoxifen-inducible cre-ERT2 from the mouse Htr6 promoter. Expression occurs in Htr6-expressing cells, including a subclass of excitatory interneurons in the dorsal horn of the spinal cord.
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| C57BL/6J-Tg(Kcnip2-cre/ERT2)NIDA099Htz/J (Cat. No.: CEMM-07250801) | Inquiry | |
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These transgenic BAC mice express tamoxifen-inducible cre-ERT2 from the mouse Kcnip2 promoter. Expression occurs in Kcnip2-expressing cells, including a subclass of inhibitory interneurons in the dorsal horn of the spinal cord.
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| B6(D2)-Tg(CAG-Brainbow1.0)3Eggn/J (Cat. No.: CEMM-07250430) | Inquiry | |
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These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage.
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| B6.Cg-Tg(Camk2a-cre)2Szi/J (Cat. No.: CEMM-07250634) | Inquiry | |
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These R1Ag5 mice express nuclear-localized Cre recombinase from the mouse Camk2a promoter in the adult brain, with high levels in all forebrain structures, and moderate levels in the cerebellum as well as testis.
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| B6J.Cg-Tg(Mnx1-cre/ERT2)8Rbro/Mmjax (Cat. No.: CEMM-07251093) | Inquiry | |
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Hb9::CreERT2 transgenic mice express a tamoxifen inducible Cre recombinase/ERT2 fusion under the control of the mouse Mnx1 (also known as Hb9) promoter elements. Cre recombinase activity is observed specifically in Hb9-expressing interneurons. This strain may be useful in studies of neural circuits.
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| C57BL/6N-Tg(Oxr1-cre)C14Stl/J (Cat. No.: CEMM-07250804) | Inquiry | |
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pOxr1-Cre mice express cre recombinase in the brain's superficial layer III of the medial entorhinal cortex (MEC). This mouse line has been used to manipulate neuronal circuits within the hippocampus and entorhinal cortex that play crucial roles in episodic memory and working memory.
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| D2.FVB-Tg(GFAP-cre)25Mes/SjJ (Cat. No.: CEMM-07250615) | Inquiry | |
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These transgenic mice express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). Recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons.
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| B6(D2)-Tg(CAG-Brainbow1.0)2Eggn/J (Cat. No.: CEMM-07250429) | Inquiry | |
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These transgenic mice carry the Brainbow 1.0 cassette, incorporating dTomato, mCerulean, and EYFP, driven by the broadly-expressed CAG (CMV-chicken beta actin) promoter. These fluorescent markers are useful in tracing cell lineage.
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| B6.FVB(Cg)-Tg(Pmch-cre)1Lowl/J (Cat. No.: CEMM-07251062) | Inquiry | |
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MCH-Cre transgenic BAC mice express cre recombinase from the mouse Pmch (pro-melanin-concentrating hormone; also called MCH) promoter/enhancer regions. These mice, backcrossed to C57BL/6J and lacking the Pde6brd1 retinal degeneration allele, are useful in studies of MCH-neuronal activity in controlling energy balance, glucose homeostasis, sleep, locomotion, and reward-related behaviors.
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| C57BL/6J-Tg(Nrl-cre)1Smgc/J (Cat. No.: CEMM-07250707) | Inquiry | |
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These Nrl-Cre mice recapitulate developmental expression patterns of the endogenous mouse Nrl gene without any overt impact on retinal structure or function. They enable rod precursor cell-specific excision of floxed genomic segments in retinal models of neurogenesis and differentiation.
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For Research Use Only.