C57BL/6N-Tg(Oxr1-cre)C14Stl/J

Cat. No.: CEMM-07250804

Common Name: pOxr1-Cre

pOxr1-Cre mice express cre recombinase in the brain's superficial layer III of the medial entorhinal cortex (MEC). This mouse line has been used to manipulate neuronal circuits within the hippocampus and entorhinal cortex that play crucial roles in episodic memory and working memory.

Inquiry

Status	Live Mouse Frozen Embryo
Age	4 weeks 12 weeks Customized Age
Sex	Male Female

GENETICS
Allele Symbol	Tg(Oxr1-cre)C14Stl show more close
Allele Name	transgene insertion C14 show more close
Allele Attributes	Recombinase-expressing show more close
Gene Symbol	Tg(Oxr1-cre)C14Stl show more close
Gene Name	transgene insertion C14 show more close
Chromosome	UN show more close
Expressed Genes	Cre, Cre recombinase, bacteriophage P1 show more close
MGI Accession ID	5300944 show more close
Site of Expression	Superficial layer III the dorsal portion of the medial entorhinal cortex. show more close
Strain of Origin	C57BL/6NTac show more close
Molecular Note	The Cre recombinase sequence was inserted by BAC recombineering methods into the translation initiation site in exon 2 of the Oxr1 gene in a BAC construct which contained the promoter region, coding sequence and a 50 kb 3' downstream region. The final vector was injected into pronuclei of fertilized C57BL/6 eggs. 16 founders were obtained and crossed with lacZ reporter mice to identify one line which displayed robust recombination in superficial layer III the dorsal portion of the medial entorhinal cortex. show more close

HUSBANDRY
Suggested Controls	C57BL/6NJ Noncarrier show more close
Breeding Considerations	Hemizygotes are viable and fertile. Homozygotes are viable, but fertility has not been tested. show more close
Breeding Strategy	Hemizygote x Noncarrier; Noncarrier x Hemizygote show more close

For Research Use Only.