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D2.FVB-Tg(GFAP-cre)25Mes/SjJ
Cat. No.: CEMM-07250615
These transgenic mice express Cre recombinase under the control of the human glial fibrillary acidic protein promoter (GFAP). Recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Tg(GFAP-cre)25Mes
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| Allele Name |
transgene insertion 25
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| Allele Attributes |
Recombinase-expressing
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| Gene Symbol |
Tg(GFAP-cre)25Mes
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| Gene Name |
transgene insertion 25
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| Chromosome |
UN
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| Expressed Genes |
Cre, Cre recombinase, bacteriophage P1
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| MGI Accession ID | show more close |
| Site of Expression |
Primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons; also periportal cells of the liver
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| Strain of Origin |
FVB/N
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| Molecular Note |
This transgene expresses Cre recombinase under the control of a human glial fibrillary acidic protein (GFAP) promoter. Cre-mediated recombination occurs primarily in the central nervous system, affecting astrocytes, oligodendroglia, ependyma and some neurons. Expression activity is also present in periportal cells of the liver. Developmental onset of transgene expression occurs in the dorsal and medial regions of the telencephalon by embryonic day 13.5. In adult cerebellum, only astrocytes are immunoreactive for GFAP or Cre recombinase.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
DBA/2J
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| Breeding Considerations |
Hemizygotes are viable and fertile. Homozygotes for this transgene are not viable. For Cre-lox experiments, researchers are urged to monitor their Cre;floxed double mutant mice for any undesirable germline deletion of the floxed allele (e.g. genotyping tail/ear samples). Researchers may consider also maintaining a GFAP-Cre colony separate from any floxed colonies.
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For Research Use Only.
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