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Mouse Models
Site-specific recombinase (SSR) system is widely used in genetically modification, especially the generation for conditional KO and inducible KO mouse models. For making it more efficient and easier, mouse models with special functions have been generated, such as tissue-specifically expressing Cre, inducible expressing Cre, Split-Cre, floxed (target gene were flanked by loxP sites) mouse, et al.
For assisting our global customers making better breakthrough in their research areas, Creative Biogene offers various of mouse models based on site-specific recombinase systems.
- Floxed Mouse: Floxed mouse models provide a way to study gene function in a controlled and tissue-specific manner, allowing researchers to investigate the roles of specific genes in development, physiology, and disease.
- Reporter Mouse: Reporter mouse models generated with SSR technology offer a means to visualize and study gene expression patterns in a tissue-specific or cell-specific manner. They are invaluable tools in deciphering the intricacies of developmental processes and disease mechanisms.
- Inducible Mouse: Inducible mouse models generated with SSR technology are genetically engineered mouse strains that allow for controlled and temporal regulation of gene expression in specific tissues or cell types.
- Recombinase-expressing Mouse: Recombinase-expressing mouse models are genetically modified mouse models that express Cre recombinase tissue-specifically or temporal-specifically.
If you couldn't find the mouse models you need or you are seeking for other model animals, please check out our gene engineering service or just feel free to contact us and get started with our trustable one-stop service.
Our Mouse Models
| B6(Cg)-Dlx5tm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250198) | Inquiry | |
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The Dlx5-CreERT2 knock-in allele in these mice both abolishes Dlx5 (distal-less homeobox 5) gene function and expresses a CreERT2 fusion protein from the Dlx5 promoter/enhancer elements.
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| B6(Cg)-Ssttm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250199) | Inquiry | |
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The Sst-CreERT2 knock-in/knock-out allele in these mice both abolishes Sst (somatostatin) gene function and expresses a CreERT2 fusion protein from the Sst promoter/enhancer elements.
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| B6(Cg)-Lhx6tm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250202) | Inquiry | |
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The Lhx6-CreERT2 knock-in allele in these mice both abolishes Lhx6 (LIM homeobox protein 6) gene function and expresses the CreERT2 fusion protein directed to the cortex by the endogenous Lhx6 promoter/enhancer elements.
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| B6(Cg)-Calb2tm2.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250280) | Inquiry | |
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The Calb2-CreERT2 (CR-CreER or CR-CreERT2) knock-in allele was designed to both abolish Calb2 (calbindin 2; also called calretinin or CR) gene function and direct CreERT2 fusion protein expression to calretinin positive interneurons in the brain by the endogenous Calb2 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
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| B6(Cg)-Etv1tm1.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250253) | Inquiry | |
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The Etv1-CreERT2 knock-in allele was designed to both abolish ets variant gene 1 (Etv1) gene function and direct CreERT2 fusion protein expression to ER81 positive neurons (including Layer5 pyramidal neurons) by the endogenous Etv1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
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| STOCK Ccktm2.1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250243) | Inquiry | |
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The Cck-CreER (or Cck-CreERT2) knock-in allele both abolishes cholecystokinin (Cck) gene function and expresses the CreERT2 fusion protein in cholecystokinin positive cortical neurons (both interneurons and pyramidal neurons) as directed by the endogenous Cck promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by the administration of tamoxifen.
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| B6(Cg)-Pvalbtm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250203) | Inquiry | |
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The Pv-CreERT2 knock-in allele in these mice both abolishes parvalbumin gene function and expresses the CreERT2 fusion protein directed to parvalbumin positive neurons in neocortex and cerebellum by the endogenous Pvalb promoter/enhancer elements.
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| B6;129S4-Dlx1tm1(cre/ERT2)Zjh/J (Cat. No.: CEMM-07250293) | Inquiry | |
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The Dlx1-CreERT2 knock-in allele was designed to both abolish distal-less homeobox 1 (Dlx1) gene function and direct CreERT2 fusion protein expression to Dlx1 positive neurons (including cortical GABAergic neurons, striatal neurons, and olfactory neurons) by the endogenous Dlx1 promoter/enhancer elements. Cre-ERT2 fusion gene activity is inducible by tamoxifen administration.
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| B6.129S6(129S4)-Pdyntm1.1Jdin/J (Cat. No.: CEMM-07251112) | Inquiry | |
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pDynfl mice possess loxP sites flanking exon 4 of the pDyn gene. After cre-mediated recombination, these mice may be useful for studying depression, nociception, anxiety, schizophrenic disorders as well as Parkinson's disease and L-DOPA-induced dyskinesia.
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| STOCK Mc4rtm3.1(cre)Lowl/J (Cat. No.: CEMM-07250825) | Inquiry | |
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Mc4r-2a-Cre knock-in mice may be useful for studying appetite control and obesity.
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For Research Use Only.