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B6.129S6(129S4)-Pdyntm1.1Jdin/J
Cat. No.: CEMM-07251112
Common Name: pDynfl
pDynfl mice possess loxP sites flanking exon 4 of the pDyn gene. After cre-mediated recombination, these mice may be useful for studying depression, nociception, anxiety, schizophrenic disorders as well as Parkinson's disease and L-DOPA-induced dyskinesia.
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| Status | Live Mouse Frozen Embryo |
| Age | 4 weeks 12 weeks Customized Age |
| Sex | Male Female |
| GENETICS | |
|---|---|
| Allele Symbol |
Pdyntm1.1Jdin
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| Allele Name |
targeted mutation 1.1
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| Allele Attributes |
Conditional ready (e.g. floxed)
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| Gene Symbol |
Pdyn
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| Gene Name |
prodynorphin
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| Chromosome |
2
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| MGI Accession ID | show more close |
| Strain of Origin |
129S6/SvEvTac
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| Molecular Note |
The allele is Created using a BAC clone containing exon 4 genomic sequence of the gene. The targeting construct was inserted into intron 3 and includes a loxP site followed by an FRT flanked neomycin/kanamycin selection cassette and a second loxP site located downstream of exon 4. FLP-mediated recombination removed the neo/kan cassette.
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| HUSBANDRY | |
|---|---|
| Suggested Controls |
C57BL/6J
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| Breeding Considerations |
When maintaining a live colony, heterozygous mice may be bred together.
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| Breeding Strategy |
Heterozygote x Heterozygote
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For Research Use Only.
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